Wednesday, June 15, 2011

June 14, 2011

Friday, December 11, 2009

Researchers finds hidden sensory system in the skin

Researchers finds hidden sensory system in the skin

Monday, November 9, 2009

Chronically Depressed? What to Do When Antidepressants Don't Work

Chronically Depressed? What to Do When Antidepressants Don't Work
The range of options includes cognitive behavioral therapy and brain stimulation techniques like ECT
Sarah Baldauf
Posted November 6, 2009

U.S. News & World Report

Sunday, October 11, 2009

Work...Not so fun right now

Last Wednesday I went back to work for the first time since the middle of July. It was so hard to walk into a place and wonder how you will be judged by everyone. Even before I got halfway down the hall my back started to cringe and hurt so badly that I had to stop to rest. I was sweating and hurting so badly. A lady even stopped to see if I was okay. Thank goodness I didn't get a full blown panic attack. After finally getting to my desk, I was so tired both mentally and physically. All day my ankles and feet were hurting and I was so tired I could barely hold my head up.

Thursday was so hard for me because I worked from home. I had things to do, but I just couldn't seem to focus on my projects. At 10:20 am, I text my husband that "I can't do this work stuff any more. It makes me too nervous and grounchy. I am so frustrated. I so want to quit. I just would like to cry cuz it makes me so unhappy." By mid morning I was already getting brain fog and having trouble concentrating. I also said, "I hate life right now. I do i do i do i do i do." By 11:00 am my back was hurting so bad I could barely stand it as well. I was ready to put in my resignation, but my husband talked me out of it.

Friday was another work from home day. It wasn't much better! I think my work situation needs to be thought about further before continuing. Good thing I have a doctor's appointment tomorrow to discuss it.

Friday, October 9, 2009

Fibromyalgia: Is Fibromyalgia Real?

Neurology Now:Volume 5(5)September/October 2009p 29-32
Fibromyalgia: Is Fibromyalgia Real?

A growing body of information suggests fibromyalgia is a true neurologic disorder.

Like many of his colleagues, John Kissel, M.D., used to think that fibromyalgia wasn't a real condition. Dr. Kissel, a neurologist and the co-director of the MDA/ALS Center at Ohio State University, thought it was a wastebasket diagnosis-a dumping ground for malingering, drug-seeking patients with unexplained pain, fatigue, and depression.


Then he saw patients that began to change his mind. He still remembers one woman in her 40s, a professional trial attorney from Columbus, OH. She had developed debilitating fatigue and horrible muscle pain and tenderness about a month after getting over a mild case of the flu.

"After performing a number of tests, I went in to speak with her and mentioned fibromyalgia," Dr. Kissel recalls. "She asked, 'What's that?' I said, 'You haven't heard of fibromyalgia? People are talking about it all over the place.' She said to me, 'I work 14 hours a day as a trial attorney-I don't do outside reading.' She wasn't depressed. She was still working. But she had all the typical symptoms of fibromyalgia. That was a formative experience in my thinking about the condition."

Today, more and more neurologists are coming around to the idea that fibromyalgia is a real disorder, and one that should be managed, or at least co-managed, by neurologists who care for chronic pain-not only the rheumatologists who originally identified the condition some 100 years ago.

"Neurologists have become more educated about the diagnosis and treatment of fibromyalgia. "- LYNNE MATALLANA, FOUNDER OF THE NATIONAL FIBROMYALGIA ASSOCIATION

Fibromyalgia has long presented a puzzle for doctors. It's considered a syndrome-a collection of related symptoms and problems without an identifiable cause-rather than a
disease. Those related symptoms include:
  • Chronic widespread pain, often accompanied by numbness, tingling, and burning
  • Multiple tender points throughout the body
  • Severe fatigue
  • Sleep problems

Pain networks in the brains of fibromyalgia patients seem to be more easily activated than in people without the disorder.

To be diagnosed with fibromyalgia, a person must have had widespread pain in all four quadrants of the body for at least three months, and tenderness or pain when pressure is applied in at least 11 of 18 identified tender points.

Fibromyalgia was originally thought to be a rheumatologic condition because-like diseases such as rheumatoid arthritis-it is characterized by musculoskeletal pain. But research has since shown that there are no abnormalities in the musculoskeletal system in people with fibromyalgia. Instead, the problem appears to lie in the pain processing pathways of our central nervous system-the bailiwick of neurologists. Today, both rheumatologists and neurologists treat fibromyalgia.

The National Fibromyalgia Association estimates that between three percent and six percent of the population has fibromyalgia-mostly women, but some men and children as well. However, with a flimsier body of research than many other chronic conditions and no blood test to diagnose the disorder, controversy has swirled around fibromyalgia for years. It's also easily confused with other conditions, such as rheumatoid arthritis and lupus (in fact, some patients have both).

Lynne Matallana, the founder and president of the National Fibromyalgia Association, originally saw a rheumatologist for her fibromyalgia. Recently she has also been seeing a neurologist to help with the overlapping conditions, such as migraines and restless leg syndrome, that also cause her distress.

"Just like everyone with fibromyalgia, I have to deal with comorbid conditions that are often treated by neurologists," Matallana says. "When I started experiencing insomnia and daytime sleepiness, for example, I was referred to a neurologist who specialized in sleep disord
ers. Unlike several years ago, neurologists have become more interested and educated about the diagnosis and treatment of fibromyalgia. As a patient this is extremely exciting because they bring a new perspective."


In the past, there has been legitimate reason for skepticism about fibromyalgia, Dr. Kissel acknowledges. "The majority of research in fibromyalgia was not adequate," he says. "Studies would pick some parameter and look at it only in patients with fibromyalgia and sometimes in normal controls, without comparing them to people with other chronic pain conditions, patients with depression, or to patients with other muscle diseases."

What's more, some physicians tended to view it as a grab-bag condition, diagnosed only when the doctor couldn't find anything else. "Patients would come in and s
ay, 'I have muscle pain.' The doctor would do all kinds of tests-electromyography [a test for abnormal electrical activity in the muscles], blood work, muscle biopsies, and imaging, and if all that was negative, then voilĂ , it was fibromyalgia," he says.

"But that's not the way you diagnose," Dr. Kissel stresses. "It's as if someone came in with a classic migraine headache and you gave the patient scans, brainwave tests, and arteriograms [imaging of the blood vessels], and if you still didn't know what it was, you said they had migraine. You diagnose migraine by what patients tell you and the way they look in the exam room, and that's the way you diagnose fibromyalgia, too."

The fact that abnormalities don't show up on standard ne
urological tests like electromyelograms and nerve-conduction studies (tests that measure how fast electrical impulses travel between nerves) is not evidence that fibromyalgia doesn't exist, says John Farrar, M.D., Ph.D., a neurologist and pain specialist at the University of Pennsylvania School of Medicine. "There may be a few people in the world who complain of [fibromyalgia] in order to get drugs and attention, but the number of real malingerers is relatively small. The patients I see have very real pain, and it's up to us as doctors to figure out what the underlying major contributors to that pain are."

It hasn't just been doctors who are skeptical of fibromyalgia-many patients have been, too. "Just recently I saw two patients who had both been to the Cleveland Clinic previously. One was the wife of a physician. They had both been told that they had fibromyalgia but neither wanted to accept it, despite the fact that they had all the criteria," says Dr. Kissel. "Probably three-quarters o
f the patients I now see with fibromyalgia have been diagnosed by another doctor, but neither the doctor nor the patient is satisfied with the diagnosis. They want another diagnosis that they think will be more treatable."


New and better research pointing to possible underlying causes of fibromyalgia seems to be winning over at least some of the skeptics. Using tools like functional MRI, which show the brain's response to pressure and heat stimuli, researchers have been able to measure how people with fibromyalgia process stimuli like pain and pressure. Some key differences have been discovered between fibromyalgia patients and those without the condition.


Researchers at the University of Michigan in Ann Arbor have found that patients with fibromyalgia have what's called a "hyperexcitable" nervous system. In other words, pain networks in their brains are more easily activated than people who don't have fibromyalgia. Other researchers have also found impairments in a specific brain region that helps to inhibit the body's response to pain among people with fibromyalgia.

"So on the one hand, people with fibromyalgia process any somatic sensory information-for example, light to moderate pressure-as painful, which comes as the result of hyperexcitability in the central nervous system," says pain specialist Miroslav Backonja, M.D., a professor of neurology, anesthesiology, and rehabilitation medicine at the University of Wisconsin School of Medicine and Public Health. "Making the problem even worse, the body's pain modulation fails to engage." The body's pain modulation system can help to "dial down" just how intensely we perceive a painful stimulus.

In this way, fibromyalgia is somewhat similar to epilepsy. "There's hyperexcitability in the nervous system on the one hand, and a failure of inhibition on the other," Dr
. Backonja says. "Which helps explain why pregabalin-a medication that is used to control epilepsy-can also be used to relieve fibromyalgia pain."

Yunxia Wang, M.D., used to be a fibromyalgia-skeptical neu
rologist as well-until treating a patient with pregabalin helped to change her mind. "Four or five years ago, a patient came to see me with a diagnosis of fibromyalgia," says Dr. Wang, a neurologist at the University of Kansas who says that about 15 percent of her practice now involves patients with fibromyalgia. "She also had multiple sclerosis. While treating her for MS, I realized that she was using her steroid medication too much. She told me it was because of pain. I wondered if it was because of the fibromyalgia, so I added her on pregabalin without changing her MS treatment. For over a year and a half, she hasn't had an attack and she's doing much better with her pain. So a patient could have an underlying neurologic disease and also have fibromyalgia."

"I think there's really been a shift, and the brain imaging is what's doing it," says Matallana. "We're seeing changes in the brain in fibromyalgia, and finally the ne
urologists are saying, 'You're talking my talk. This is interesting and I don't want to be left out.'"

Not all neurologists are embracing fibromyalgia, however. "It's a difficult condition to take care of. The patients have chronic pain, they call a lot, and they tend to have a lot of comorbidities," says Dr. Kissel. Comorbidities are other conditions that exist alongside the main disorder-with fibromyalgia they often include depression, anxiety, headache, irritable bowel syndrome, chronic fatigue syndrome, lupus, and rheumatoid arthritis. "They're very much like chronic headache patients in this regard."

Matallana agrees that the interest in fibromyalgia among neurologists at this point is largely among researchers, pain specialists, and those at academic centers. "I don't think it's trickled down to the average neurologist in practice yet, she says. But that may change soon."


But Dr. Backonja argues that neurologists, especially those who specialize in pain, have a responsibility to take fibromyalgia on. "It would be scary and sad for our profession if mounting scientific information were ignored," he says. "There's a growing body of information clearly pointing to this as a neurological disorder, and while we can't cure it, there is a pretty reasonable way to apply treatment strategies."

There are now three medications approved by the Food and Drug Administration (FDA) for the treatment of fibromyalgia. In addition to pregabalin, which was the first to gain approval, duloxetine and milnacipran can also be prescribed for fibromyalgia. Duloxetine is also approved for the treatment of depression, anxiety, and painful diabetic neuropathy; and milnacipran for the treatment of depression. Doctors may also prescribe low doses of antidepressants to boost serotonin levels, helping to improve sleep and relieve pain.

"In addition to medication, the patient needs to be engaged in figuring out how to help him- or herself," says Dr. Farrar. "This can include physical therapy, rehabilitative exercise, yoga, self-hypnosis, biofeedback-things that allow the brain to be retrained to help deal with the pain. None of these are right for everybody, of course. For example, some people prefer exercise therapy to yoga."

How successful are these treatments? For people initially diagnosed with fibromyalgia, Dr. Farrar says that the chances of neurologists being able to help make them at least somewhat better or manage their pain are high-about 75-to 90-percent. "By the time someone comes to see a specialist, they have probably had some of the simpler therapies, so the likelihood may have gone down a bit. But we're always able to help people in some way. We work with the patient to focus on what works and what doesn't, helping them to manage their discomfort and disability."

More options are on the horizon, as scientists learn more about pain and the nervous system in general and fibromyalgia in particular. "We're learning a lot more about nerve-related pain, and although there aren't any obvious pathways that are focused on fibromyalgia, there are still some new agents that I think will allow us to begin to treat patients for underlying abnormalities," says Dr. Farrar.

He predicts that the prospects for at least two or three additional therapies for fibromyalgia over the next 10 years are very good. "That said, people shouldn't set their expectations too high, he says. I doubt we'll be able to get to the point where there is zero pain, but we can make it like arthritis-the pain is there, but people are functional and can do the things they need to do."

Copyright © 2009, AAN Enterprises, Inc.;jsessionid=KPZLZ6HwBcLkxYd4LCywjkgWP30r0rjzpbJvGfbs00788TGFGJJv!-2135654213!181195629!8091!-1

Chronic fatigue and fibromyalgia similar

Chronic fatigue and fibromyalgia similar
By JACQUE ARNOLD • For the Tribune • October 5, 2009

A formal definition was done by the Center for Disease Control in 1988 for chronic fatigue syndrome in an attempt to establish guidelines for evaluation by physicians. However, the criteria were controversial for several reasons: one being they left out most of the psychological symptoms.

Depression, anxiety and impaired mental function are in the top 10 symptoms given by 50 percent or more of chronic fatigue patients. Also, many of the common symptoms like allergies, PMS, stiffness, dry eyes and mouth, cough and dizziness were ignored.

The CDC's major new criterion is onset of fatigue causing a 50 percent reduction in activity for at least six months and the exclusion of other illnesses that can cause fatigue. Minor criteria are related to the presence of eight out of 11 symptoms or six out of the 11 and two out of the three signs. The signs are listed as low-grade fever, sore throat and enlarged painful lymph nodes.

The Epstein-Barr virus has been suggested as a possible cause of chronic fatigue syndrome. Research shows that by adulthood, almost everyone has measureable Epstein-Barr antibodies in their blood, indicating past infection. Like many viruses, Eptstein-Barr virus can lay dormant until the immune system becomes compromised allowing the virus to reactivate. Research has added eight more viral agents to the list of possible causes of chronic fatigue syndrome.

Fibromyalgia receives much less attention in the research. The only difference in diagnostic criteria between chronic fatigue syndrome and fibromyalgia is the requirement for musculoskeletal pain in fibromyalgia and fatigue in chronic fatigue syndrome. In fact in one research group they found that 70 percent of the patients diagnosed with fibromyalgia met the CDC's criteria for chronic fatigue syndrome.

A diagnosis of fibromyalgia requires that presence of the three major criteria which are generalized aches and stiffness of at least three different sites on the body for at least three months, six or more consistently tender points on the body and the exclusion of other disorders which can cause similar symptoms.

There are many underlying health problems such as low thyroid which you know can cause fatigue but it can also cause variable muscle aches and pains. Other health issues include an increase in gastrointestinal permeability (leaky gut) and impaired liver function because of exposures to chemicals, heavy metals like mercury and aluminum, pesticides and herbicides.

New research suggests that the ability of the body to adequately transform toxic metabolites formed from both internal metabolism and external xenobiotic exposure may be related casually to the puzzling diseases chronic fatigue and fibromyalgia. This research also suggests that there is a relationship between impaired detoxification pathways and the symptoms of chronic fatigue and fibromyalgia. A sluggish, unbalanced or impaired detoxification system can result in the accumulation and deposition of metabolic toxins in the body, causing increased free radical products and decrease energy production.

Liver detoxification has two pathways — phases I and II. Phase I is increased by alcohol, smoking and certain medications which in turn taxes phase II. Antidepressants such as Prozac, oral birth control pills and H2 blockers used in acid reflux, decrease phase II which prevents adequate breakdown and elimination of other toxins, causing them to accumulate.

The naturopathic treatment approach involves multiple therapies which address the individual specific clinical picture. Detoxification is commonly part of a naturopathic treatment plan. Above, I mentioned the livers detox pathways and how they can be affected. You can make yourself very ill doing an unsupervised detox program, so I highly recommend you see one of the four fabulous naturopaths in our community. They can devise a safe detox program just for you.

Sunday, September 20, 2009

Could Your Symptoms Be Depression |

Could your Symptoms Be Depression?